A member of security was threatened with a hammer as he tried to stop the suspects. He was not injured.
About 10 suspects on five mopeds made off with a quantity of clothing from Canada Goose, which only opened a few days ago.
The suspects fled on their scooters.
Police believe the theft may be linked to an attempted smash-and-grab at a clothing store on St John’s Wood High Street at o1:30hrs on Monday. They left empty-handed
The break-in comes just 24 hours after 10 suspects on five scooters smashed their way into Apple’s Regent Street store across the road.
Crimes involving powered-two-wheel vehicles in London, is up from 5,145 in 2016.
The force has deployed remote-controlled spikes, DNA tagging sprays and slimmer police motorbikes.
At the time the Met Commissioner Cressida Dick said she was shocked by the “extraordinary rise” in moped crime.